Even though the cytotoxicity was high especially for the emulsion, genotoxicity was not determined.

The result of biofilm eradication assay was confirmed by scanning electron microscopy. Compared to essential oil, the efficacy of emulsion was even stronger considering the small share of pure oil (20%) in the emulsion. Both substances exhibited significant antibacterial (minimal inhibitory concentrations in the range 0.125–0.5 mg/ml) and antibiofilm effects (inhibitions of formation and reduction of pre-formed biofilm were 47–81 and 30–62%, respectively). Synthesized emulsion was characterized with Fourier-transform infrared spectroscopy and photon correlation spectroscopy. The cinnamon emulsion was synthesized from cinnamon essential oil by combining modified low- and high- energy methods. Gas chromatography–mass spectrometry of essential oil indicated trans-cinnamaldehyde as the most abundant component.

Furthermore, the investigation of toxicological aspects of possible applications of essential oil and emulsion was done as well. The aim of this study was comparative analysis of cinnamon essential oil and its emulsion against biofilm forming A. Still, further increase of antibacterial efficacy and improvement of bioavailability of cinnamon oil is possible by emulsification process. One of them, which has already been proven to possess a wide spectrum of biological activities, including antimicrobial effect, is cinnamon essential oil. Therefore, searching for new potent agents that are efficient against A.

4Institute of General and Physical Chemistry, Belgrade, SerbiaĪcinetobacter baumannii is an emerging nosocomial pathogen resistant to a wide spectrum of antibiotics, with great potential to form a biofilm, which further aggravates treatment of infections caused by it.3Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade, Belgrade, Serbia.2Group for Biomedical Engineering and Nanobiotechnology, Institute of Technical Sciences of SASA, Belgrade, Serbia.1Faculty of Biology, University of Belgrade, Belgrade, Serbia.Tea Ganić 1, Stefana Vuletić 1, Biljana Nikolić 1, Magdalena Stevanović 2, Maja Kuzmanović 2, Dušan Kekić 3, Saša Đurović 4, Stefana Cvetković 1 and Dragana Mitić-Ćulafić 1 *

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